Abstract: Objective To investigate the expression and clinical significance of VEGF-C and COX-2 in bronchioalveolar carcinoma (BAC). Methods 60 cases of BAC were enrolled in experimental group；the control group contained 20 cases of pulmonary adenocarcinoma with BAC features and 22 cases of pulmonary adenocarcinoma. Expressions of VEGF-C and COX-2 were detected by immunohistochemical. Results Positive rates of VEGF-C in BAC，pulmonary adenocarcinoma with BAC features and pulmonary adenocarcinoma were 66.7%，90.0% and 95.5% respectively，the difference of which was statistically significant (P＜0.01). The positive rates of VEGF-C were notably higher in non-mucinous BAC than that in mucinous (P＜0.01)，and in lymphonode metastasis than in that without lymphonode metastases (P＜0.05). The positive rate of VEGF-C was not correlated with patients’ gender and age，and the localization，size and TNM stage of tumor (P＞0.05).  Positive rates of COX-2 in BAC，pulmonary adenocarcinoma with BAC features and pulmonary adenocarcinoma were 63.3%，75.0% and 77.3% respectively，the difference of which was not statistically significant (P＞0.05). The positive rates of COX-2 were obviously higher in lymphonode metastasis than that without lymphonode metastases (P＜0.05)，in tumor with diameter >3cm than that with diameter <3cm (P＜0.05). The positive rate of COX-2 was not correlated with patients’ gender and age，and the localization，size，histological type and TNM stage of tumor (P＞0.05).The expression of VEGF-C was positively correlated with that of COX-2 (r=0.269，P＜0.05). Conclusion Combined detection of VEGF-C and COX-2 could be applied in assessing and predicting the invasion and metastasis of BAC.

Key words: Bronchioalveolar carcinoma, COX-2, VEGF-C, Metastasis